Synthesized peptide derived from the Internal region of human PARP-1
WB 1:500-2000, IHC 1:50-300, IF 1:50-300
Nucleus. Nucleus, nucleolus. Localizes at sites of DNA damage.
Store at -20℃. Avoid freeze / thaw cycles.
PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.