Antibody  

Cleaved-PARP1 (D214) Polyclonal Antibody B-IO-10204

Overview

SynonymsADP-ribosyltransferase diphtheria toxin-like 1,ADPRT 1,ADPRT,ADPRT1,APOPAIN,ARTD1,NAD(+) ADP-ribosyltransferase 1,PARP,PARP-1,PARP1,PARP1,Poly [ADP-ribose] polymerase 1,Poly ADP ribose polymerase 1,Poly[ADP-ribose] synthase 1,PPOL,SCA1
SwissprotP09874
SourceRabbit
ReactivityHuman,Mouse
ImmunogenSynthesized peptide derived from the Internal region of human PARP-1
ApplicationWB,IHC-p,IF,ELISA
Recommended dilutionWB 1:500-2000, IHC 1:50-300, IF 1:50-300
Concentration1mg/mL
ClonalityPolyclonal

Properties

Cellular localizationNucleus. Nucleus, nucleolus. Localizes at sites of DNA damage.
IsotypeIgG
PurificationAffinity purification
ConjugationUnconjugated
Storage instructionsStore at -20℃. Avoid freeze / thaw cycles.
Storage bufferPBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
BackgroundThis gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

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