| Synonyms | dJ576K7.1 (FK506 binding protein 12 rapamycin associated protein 1),FK506 binding protein 12 rapamycin associated protein 1,FK506 binding protein 12 rapamycin associated protein 2,FK506 binding protein 12 rapamycin complex associated protein 1,FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP rapamycin associated protein,FKBP12 rapamycin complex associated protein,FKBP12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,FLJ44809,FRAP,FRAP1,FRAP2,Mammalian target of rapamycin,Mechanistic target of rapamycin,mTOR,MTOR,OTTHUMP00000001983,RAFT1,Rapamycin and FKBP12 target 1,Rapamycin associated protein FRAP2,Rapamycin target protein 1,Rapamycin target protein,RAPT1,Serine/threonine-protein kinase mTOR |
| Swissprot | P42345 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human MTOR |
| Application | WB,IF,IP |
| Recommended dilution | WB 1:500 - 1:2000 IF 1:50 - 1:200 IP 1:50 - 1:100 |
| Concentration | 1mg/ml |
| Clonality | Polyclonal |
| Cellular localization | Endoplasmic reticulum membrane. Golgi apparatus membrane. Mitochondrion outer membrane. Lysosome. Cytoplasm. Nucleus > PML body. Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity). Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Background | The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. |
